Relevance of food allergy in the assessment of NSAID-involved reactions

Method We prospectively recruited all consecutive patients from June 2012 to May 2014 consulting for an NSAID adverse reaction in which a confirmation diagnosis was reached. The practical approach to the diagnosis of hypersensitivity to NSAIDs was performed according to the protocol from the EAACI Task Force on NSAIDs Hypersensitivity. SPTs were also performed to a standard panel of inhalant and food allergens. Food allergy was assessed by a consistent clinical history and a positive SPT to the foods involved. A subgroup of patients diagnosed as NSAIDenhanced food allergy was challenged with the responsible food in the presence and absence of the NSAID to demonstrate the enhanced effect.